Kratom, as well as isolated alkaloids isolated from it, is of great importance for official medicine. Back in 1897, in the description of the traditional use of Kratom, it is mentioned that its leaves are an effective treatment for opiate addiction.
New research in New Zealand talks about the successful use of mitrajinin for the treatment of methadone addiction.
It is reported that the patient smoked the dry leaves of the kratom when experiencing withdrawal symptoms daily for 6 weeks. The patient also reported vivid hypnagogic dreams while using the kratom. In the United States, as part of an experimental study of ibogaine, as an active means of treating drug addiction, the activist of the Healing, not War movement Dana Beale proposed using Mitrajinin, the dominant active kratom alkaloid, in comparative experiments.
However, the acting deputy director of NIDA, Charles Grudzinskas, rejected this proposal, arguing that there was even less reliable scientific information about mitrajine than about ibogaine.
Despite the fact that zagain and mitraginine are chemically similar to each other (they are indole derivatives), and interact with opioid receptors, their pharmacological effects have serious differences. If zagain is usually used for a single dose, then it can be used as a means of “substitution therapy,” like methadone.
The big plus of Kratom is that he has a legal legal status in most countries of the world, and this is today one of the safest means capable of eliminating the acute manifestations of the syndrome in patients.
It is a cheaper and safer alternative to methadone. There are currently many reports of the successful use of Kratom for detoxification, even with severe forms of opium addiction. At the same time, people who have high hopes for using Kratom in self-treatment and drug addiction should clearly understand that Kratom, although potentially safe and effective means with uncontrolled and long-term practice, is hardly useful, rather the opposite googling.
Of great interest is also the use of Kratom in the treatment of acute and chronic pain syndrome on the background of the use of “classic” opioid analgesics, since it may reduce the dosages of the latter while maintaining a high level and quality of analgesia. In addition, in this case, you can achieve a slowdown in the development of tolerance to morphine-like substances and, therefore, in general, slow down the development of physical dependence on them.
In addition to psychotropic activity, Kratom also has a number of urgent properties that are caused by the presence of many other biological active substances in the leaves. Among them are substances with pronounced antioxidant, immunostimulating properties, with antibacterial and antiviral activity and substances that have an effect on the cardiovascular system. Some sources even report on the anticarcinogenic properties of plants.
It seems very effective to use Kratom as an alternative to codeine in various antitussives. Unlike codeine and other opiates, Kratom has a significant advantage – it does not inhibit respiration, and contributes to the discharge of sputum, and does not prevent it; In addition, one should not forget about the antibacterial and immunostimulatory properties of it in the treatment of infectious diseases of the upper respiratory tract. These properties of Kratom are also very appropriate in cases of treatment of pain syndrome after some surgical interventions, since this would reduce the risk of developing infectious complications in such cases. In terms of the effectiveness of analgesia, Kratom is approximately comparable to codeine and some of its derivatives, while individual leaf alkaloids, often referred to as “opioid analgesics, are tens of times superior to morphine,” showed rather unexpected results. In the early 1970s, the pharmaceutical company Kline and the French pharmacological laboratory conducted an experiment on mitraginine by introducing an isolated alkaloid to humans. In a personal letter to Karl Jansen in 1986, Raffauf reported that this study was discontinued due to unacceptable acute side effects. He wrote: “It is likely that the possible cause of this phenomenon is the pharmacological differences between isolated Mitrajinin and the natural leaves of Kratom, which contain many other active alkaloids.” Pure Mitrajinin causes nausea, vomiting, double vision, muscular disorders and adverse effects on the cardiovascular system. Therefore, by default, it cannot be used in its pure form as an analog of a number of street drugs of the opium series, and this is another important feature of Kratom and its alkaloids in particular.
In 1999, Pennapa Spcharon, director of the National Institute of Thai Traditional Medicine in Bangkok, said that Kratom may be prescribed for patients suffering from depression, but stressed that this requires a lot of additional research, and any potential use of Kratom in drug treatment should be considered exclusively in the framework of complex therapy.
Thus, if in the ethnic medicine of many countries where the plant Mitragyna speciosa grows wild, all sorts of preparations from its leaves have been successfully used since ancient times by folk healers for a wide variety of pathologies and symptoms, Western official medicine is only just beginning to become acquainted with this amazing plant.