Kratom in the fight against free radicals and diseases related to them
The human organism is composed of cells that need energy to perform their vital functions normally. They obtainit during cellular respiration, an oxidation process in which glucose and fattyacids consume oxygen and produce ATP (adenosinetriphosphate) and energy. But, this process is not perfect and other molecules are also produced, among them the so-called free radicals. These Substances are atoms or molecules that have one or more unpaired electrons in their orbitals, this being a chemically very unstable situation since the lone electron looks for a pairto complete the orbital, so these atoms or molecules subtract an electron for many molecule neighbor, oxidizes this molecule, altering its structure, damagingit andconverting it into another free radical, thus generating a chainreaction. Free radical thus deteriorate the cells until they are destroyed.
Free radicals are naturally generated by our body and to a certainextent are not always harmful. Its highly reactive and destructive nature is used by the body's immune system. For example, certain white blood cells, called phagocytes, can wrap foreign particles, such as bacteria, then seal them and release free radicals to destroy them.
Our bodies can manage a certain level of free radicals, but if too many are formed, they can seriously damage the body's normal defenses. Free radicals can be increased by factors related to lifestyle such as stress, poordiet, air and water pollution, tobacco, etc.
The Body Defend Itself Against The Harmful Action of free radical through antioxidant systems, so that free radicals and antioxidants are balanced and damage is minimized.
Antioxidants are compounds that traporneutralize free radicals, giving them an electron which activates them and neutralize the chain process through which the damage they produce ispropagated. These antioxidants do not transform into free radicals dueto the great mobility of their electrons, orifthey do, they are of low reactivity.
When the balance between free radicals and antioxidants is lost in favor of the former, oxidative stress occurs, which is associated with the development of numerous diseases, such as cancer, arteriosclerosis, inflammatory processes, cataracts, Parkinson's disease, etc. And in addition, the biological process of aging accelerates in direct relation with oxidative stress.
Antioxidants can be endogenous, produced by our body, orexogenous, found in food.
Among the antioxidants that enter in our body through food we can high light the antioxidant vitamins, carotenoids and polyphenols, which are animportant group of compounds present in fruits and vegetables and drinks such as tea and wine.
In the estimation of the composition of the kratom extract (mitragyna speciosa) a tree of the coffee family, the phytochemicals found in various parts of the tree include flavonoids, saponins, terpenoids and polyphenols among other antioxidants. These have extensive literature associated with their antioxidant action but what has been recently tested in a study is the antioxidant value and antiproliferative efficacy of mitragynine (MTG) one of the pare dominant alkaloids responsible for the effects of kratom (Goh TB, KohRY ,Mordi MN, Mansor SM. '' Antioxidant value and antiproliferative efficacy of mitragynine and a silane reduced analogue ''.)
The study was carried out by DPPH essays that makes use of the stable radical DPPH (2,2-Diphenyl-1-picrylhydrazyl), which has a strong purple color that can be measured spectrophotometrically.
The findings in the values of them it rage nine analogues make it appear as a new source of antioxidants to prevent the progress of various diseases induced by oxidative stress, including cancer. In addition, this study justifies the efficacy of the analogues related to mitragynine as possible anti-cancer and chemopreventive drugs.